Oligoclonal Band versus Chitinase 3 Like 1 Protein in CSF of Newly Diagnosed Relapsing Remitting Multiple Sclerosis

Abstract

Multiple sclerosis (MS) is a chronic autoimmune-mediated demyelinating disease of the central nervous system (CNS) that is usually associated with varying degrees of progressive disability. In most patients the early stages of disease, known as relapsing remitting MS (RRMS) are characterized by clinical exacerbations, or relapses, caused by autoreactive immune cells that traffic into the CNS, resulting in focal inflammation and demyelination often visible as gadolinium-enhancing lesions on magnetic resonance imaging (MRI). Relapses are followed by periods of clinical remission as inflammation resolves and remyelination occurs.