A randomized controlled clinical trial of Trisodium Citrate 30 % versus Heparin as a lock solution for the prevention of catheter-related infections in adult hemodialysis patients

Abstract

The prevalence of end-stage renal disease (ESRD) requiring renal replacement therapy (RRT) has increased in the last decade, and it is expected a continuous increase over the next years. Hemodialysis (HD), the main modality of RRT, depends on long term and effective vascular access. For chronic hemodialysis treatment, an arteriovenous fistula or graft is preferred for vascular access. However, In case of acute kidney injury, sudden deterioration of chronic kidney disease, AVF occlusion or maturation failure, alternative vascular access is needed