The Possible Therapeutic Effects of Resveratrol and/or Quercetin on Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats.

Abstract

The current study was carried out on adult male albino rats to examine the possible therapeutic effects of resveratrol and/or quercetin on some biochemical and haematological parameters linked to diethylnitrosamine (DENA)-induced tuomor inflammation, angiogenesis, hepatocellular carcinoma and coagulation-fibrinolysis abnormalities.

This work which was included two experiments. In the first experiment, the animals were classified into two main groups: A. Control group (C): thirty one rats served as normal control and were treated with vehicle intraperitoneally, received 1 ml normal saline (0.9 % NaCl).

B. Hepatocellular carcinoma group (HCC): ninety four rats received intraperitoneal injection of DENA 100 mg/kg of body weight dissolved in normal saline (0.9% NaCl) solution once per week for three weeks. One week after the final dose of DENA. The rats received an intraperitoneal injection of PB 100 mg/kg once per day for 7 successive days.