Possible Ameliorative Effect of Dihydroxyflavone on a Rat Model for Parkinson’s Disease

Abstract

Parkinson's disease (PD) is one of the most common neurodegenerative diseases (NDDs), affecting primarily the elderly and characterized by severe motor and non-motor symptoms. NDDs are expected to surpass cancer as the world's second most common cause of death by 2040. The etiology and pathology of Parkinson's disease are not totally understood. Furthermore, no effective medication without side effects for Parkinson's disease is currently available. The purpose of this study was to assess and compare the modulatory impact of chrysin (50 mg/kg, oral), L-dopa (10 mg/kg, oral), and the combined treatment of chrysin (50 mg/kg, oral), with half-dose L-dopa (5 mg/kg, oral) given for 28 days on experimentally induced PD in male Wistar rats. PD model was induced by subcutaneous injection of rotenone (1.5 mg/kg, every other day for 21 days). The results of the current study displayed that rotenone had a bad effect by causing a significant decrease (P < 0.05- 0.001, compared to the control group) in the rotarod means fall-off time, concentration of neurotransmitters (Norepinephrine (NE), Dopamine (DA), and Serotonin (5- HT)) in midbrain and striatum, burst interval and