EFFECT OF NANO-SELENIUM AND MOLECULAR HYDROGEN ON BIOLOGICAL SYSTEM UNDER OXIDATIVE STRESS

Abstract

Oxidative stress is one of the factors that greatly affect the biological parameters in humans and animals and that activate the production of free radicals. It is known that the organism is equipped with defense systems against oxidative stress factors, and these systems are either enzymatic SOD, CAT and GR or non-enzymatic antioxidants such as reduced glutathione GSH, which reduces unwanted free radical produced from oxidative stress and works to create a state of equilibrium and remove those free cracks. This study aims to find a solution to the problem of physical (hazard as rays) and chemical oxidative stress, The first comes as a result of exposure to radiation, such as UV rays specially UVA, while the second is caused by chemicals and pollutants that enter the biological system of the living organism. The current study, will investigates two types of stress factors, the first chemical using the thioacetamide (TAA) compound, and the second physical by using ultraviolet (UVA) rays by treating each of them on white experimental mice during a period of time up to three months at least, and trying to remove these two types of chemical and physical oxidative stress using Two types of treatments, the first using selenium Nanoparticles (SeNPs) and the second by molecular hydrogen (H2) or hydrogen rich water (HRW), by designing four experiments on white male albino rats as follows: The first experiment: included untreated normal control group SeNPs group HRW group and both SeNPs + HRW group. The second experiment: chemical oxidative stress that induced stress by thioacetamide (TAA) injection into the peritoneum in male albino rats, then treated with selenium Nanoparticles (SeNPs), hydrogen rich water (HRW) and combined SeNPs + HRW.