BIOLOGICAL ACTIVITY OF SOME LOCAL ISOLATES OF ACTINOBACTERIA

Abstract

Biological Activity of some Local Isolates of Actinobacteria Actinobacteria represent the most prominent group of microorganisms, which produce a vast number of bioactive compounds especially the Streptomyces genus which is the richest source of natural products especially antibiotics, enzymes, vitamins, hormones and other bioactive compounds. Streptomyces strains are potent producers of a wide range of secondary metabolites with diverse biological activities, which include medicinally and agriculturally important compounds. The research aims to study the biological activity of some local strains of actinobacteria, with aims to produce antimicrobial substances and using them in the biological control of some phytopathogenic microorganisms. To achieve this goal, the following steps were performed: 1. Isolation of some local isolates of actinobacteria from different Egyptian soils. 2. Purification and identification of the local isolates up to genus. 3. Screening the purified actinomycete isolates according to their biological activities (antimicrobial activity). 4. Selection and identification of isolate showing high biological activities up to species. 5. Optimization of growth and productivity of the most active strain. 6. Application experiments for the use of antimicrobial substances produced by the selected strain to biocontrol of phytopathogenic microorganisms.