Prognostic Value of C - Reactive Protein in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Admitted to Intensive Care Unit

Abstract

Chronic obstructive pulmonary disease (COPD) is a leading and increasing cause of worldwide morbidity and mortality. Recently, COPD has gained interest as a major public health concern and is currently the focus of intense research because of its persistently increasing prevalence, mortality, and disease burden. COPD is the third leading cause of death in the world, and further increases in its prevalence and mortality can be predicted in the coming decades. It is increasingly recognized that COPD involves several systemic features, particularly in patients with severe disease, and that these have a major impact on survival and comorbid diseases. Increased concentrations of inflammatory mediators, including TNF-α, IL-6 and oxygen derived free radicals, may mediate some of these systemic effects. There is an increase in the risk of cardiovascular diseases, which is correlated with an increase in CRP. The aim of the present work was to detect the possible role of CRP levels in predicting the prognosis of ICU admitted patients with AECOPD. This prospective Cross sectional study was conducted on 66 adult patients of both sexes admitted to the ICUs of Al-Mabarra governmental hospital in Port Said and Ain Shams University Hospitals.