The Association Between Trace Elements And Depression Among Elderly Patients With Chronic Liver Disease

Abstract

CLD causes significant morbidity and mortality worldwide, so it is an important public health issue globally. Depression is the most common neuropsychiatric disorder among older people, and it has a significant impact on the QOL. Patients with CLD have a higher incidence of depression than that in healthy population, it may be due to accumulation of neurotoxic in blood and the accumulation of pro-inflammatory cytokines in the brain. The human body is composed of elements that is divided into macro-minerals and TEs. The liver regulates the transport, excretion of macro-minerals and TEs through bile formation. The concentration of each macro-mineral and TE differs with different types of CLD since these elements may have a direct hepatic toxicity or may be decreased as a result of liver function impairment. Macro-minerals and TEs levels are linked with the etiology and pathophysiology of many mental disorders, including depression.