Topical delivery systems for a natural product

Abstract

Skin cancer is the most widely diagnosed type of cancer in Caucasian populations. Basal cell carcinoma (BCC) represents 70% while squamous cell carcinoma (SCC) represent 25% of non-melanoma skin cancer. Nanotechnology-mediated approach has been considered one of the most powerful strategies to enhance skin penetration of various small as well as large molecular weight drugs for the treatment of various skin disorders including skin cancer. Nanocarriers could achieve a sustainment in drug release, hence reduce adverse effects such as skin irritation, skin scaling, swelling and inflammation caused by repetitive application of topical medications previously reported for topical skin cancer treatment such as 5-fluorouracil which limited their use in management of disease.