CORRELATION OF INTRAVENOUS VITAMIN C INJECTION AND PLASMA ALBUMIN LEVEL IN BURNT RATS (EXPIRAMENTAL ANIMAL STUDY)

Abstract

evere burns require appropriate fluid management in the acute phase. A massive volume of intravenous fluid is usually required to ensure adequate end-organ perfusion. Also, reactive oxygen species contribute to increased endothelial permeability. Vitamin C, or ascorbic acid, is an inexpensive and readily available antioxidant commonly deployed in the clinical settings. Several preclinical studies and two clinical studies demonstrated that high-dose vitamin C can reduce fluid infusion and subsequent edema. The aim of this study was to detect the efficacy of intravenous vitamin C and plasma albumin level in burnt rats. This study was an experimental study on 14 rats only not including any human and they were divided into two groups: Group A that represented burnt rats that weren’t injected with vitamin C and Group B represented burnt rats that were injected with vitamin C. Statistical analysis revealed the following: 1- There was no statistically significant difference found between two groups regarding albumin level and total proteins level before burn and Post burn 8h.