"Analytical Study on Certain Drugs For Treatment of Conjunctivitis"

Abstract

Summary This thesis is concerned with the analysis of certain drugs used in treatment of conjunctivitis namely; Prednisolone acetate, Sulfacetamide sodium and Tobramycin sulphate. The thesis includes six parts: PART (I): Introduction and Literature review It includes a brief idea about conjunctivitis, drugs used for its treatment, review of their structures, their chemical and physical properties and different analytical methods reported in literature applied for the determination of the studied drugs in pure form, pharmaceutical formulations and biological samples. PART (II): Spectrophotometric Methods for Determination of Certain Drugs used in Treatment of Conjunctivitis Section (A): Spectrophotometric Methods for Simultaneous Determination of Prednisolone acetate and Sulfacetamide sodium in Bulk Powder and in their Combined Dosage Form. Four validated eco-friendly spectrophotometric methods were described for the simultaneous quantification of Prednisolone acetate and Sulfacetamide Sodium in their pure form and their pharmaceutical formulation. Two smart spectrophotometric methods using unified regression equation namely Response Correlation and Amplitude Modulation and two other ratio spectra manipulating methods namely; Ratio subtraction and Ratio difference coupled with constant multiplication were developed and validated for the simultaneous analysis of a binary mixture of the mentioned two drugs. The proposed methods were validated according to ICH guidelines and were found to be within the acceptable ranges.