A comparative Study Between Needling and Homologous Autoimplantation Techniques in Treatment of Multiple Plantar Warts

Abstract

arts are a common dermatologic complaint resulting from infection with HPV which spread by direct skin-to-skin contact or by autoinoculation. The clinical appearance of warts is variable depends on the type of HPV involved and the site of infection. There are various types of viral warts including common warts, plantar warts, plane warts and genital warts, usually diagnosis of warts is made through clinical examination of the lesions and no laboratory investigations are required. Multiple treatment modalities are available for treating different types of warts, most treatments directly destroy the visibly infected tissue. However, tissue damage alone may not be enough to produce the relevant cytokines to destroy latent virus in adjacent cells.Therefore, immunotherapy seems to be a promising modality in such cases and manipulating the immune system to achieve HPV-targeted immune reaction offers a theoretical advantage of obtaining an effective and sustained control of viral replication and preventing recurrence. Previous reaserches on successful treatments have been aiming toward creating an enhanced systemic immune response to eradicate the virus including immunotherapy with candida albicans, tuberculin purified protein derivative (PPD) and measles, mumps, and rubella (MMR)vaccines. Moreover, one of these researches including the needling procedure,other including autoimplantation technique. Both act by activation of self-cell mediated immunity against HPV