“The Effect of Adipose Derived Stem Cells versus Platelet rich plasma on Submandibular Salivary Glands of Albino Rats Receiving Cisplatin.”

Abstract

Cisplatin as a chemotherapeutic agent has been indicated for the treatment of various tumors or prior to radiotherapy and surgery. However, chemotherapeutic agents can lead to morphologic damage in salivary gland tissue (Mittal et al., 2015). There are many clinical studies and researches which have looked into salivary gland damage-regeneration through ADSCs application, by means of systemic and local use. Both animal and human experiments have verified that ADSCs could represent a safe treatment strategy for salivary gland damage (Lombaert et al., 2017). Platelet rich plasma has been the subject in different studies in medicine, but there was lack in studies handling the effect of PRP injection on SMG after chemotherapy.

- AIM OF THE WORK: In the present study we aimed to test the hypothesis that PRP could play a role in the improvement of the structural changes that could occur in the cisplatin treated SMGs. In addition, we aimed to compare the possible treatment effect of both ADSCs and PRP and find out which is more effective and profound.