Nitrogen and oxygen containing compounds as building blocks in synthesis of some heterocyclic compounds

Abstract

In this study, a new series of quinazoline and their annulated deriva- tives have been synthesized. A number of quiazolinone derivatives substituted at position-3 were prepared from 3, 1-benzoxazinone by the treatment of 3,1-benzoxazinone with different nitrogen nucleo- philes such as, hydrazine hydrate, phenylhydrazine, ethanolamine, and cyano acetohydrazide afforded the quinazolinone derivatives 7–11. The reaction of hydrazide derivative 5 with aromatic aldehydes gave the Schiff’s bases derivative 16a–c. Some of the synthesized com- pounds were tested against the breast cancer cell line (MCF-7). The structures of all the newly synthesized compounds were established based on IR, 1H, 13C NMR, mass spectral data, and elemental analyses