Study of Platelet Rich Plasma Injection versus Plasma Gel in Periorbital Rejuvenation

Abstract

ging of the skin consists of a combination of genetically predisposed factors (intrinsic aging) and environmental factors (photo aging). The resulting clinical manifestations include mottled pigmentation, wrinkles, and change of the superficial texture leading to coarseness of the skin. Platelet Rich Plasma; an autologous source of platelet derived growth factors may play a role in periorbital rejuvenation. There are many suggested mechanisms of rejuvenation by PRP such as increased proliferation of human dermal fibroblasts, increased expression of Matrix Metalloproteinase (MMP-1 and MMP-3), increased production of procollagen type 1 peptide and expression of collagen type1-alpha 1 leading to synthesis of new collagen. Several new approaches based on autologous plasma fillers have been introduced for periorbital rejuvenation and correction of aging with variable results and outcomes. Usual use of fillers in periorbital area has been suggested to cause several side effects including arterial embolization, occlusion of ophthalmic artery, blindness, erythema and edema while laser resurfacing and radiofrequency technology in the same area for rejuvenation usually causes erythema, hyperpigmentation and demarcation lines. Also neuromodulation which may cause eyelid and eyebrow ptosis, bruising, pain and erythema. Moreover chemical peels used for rejuvenation in periorbital area may induce hyper or hypo pigmentation and usually disables the patient from recovering for at least 15 days and may induce keloid formation. Thus new lines of therapy are continuously on demand to avoid these complications (Choi et al., 2017).