BIOLOGICAL ACTIVITY OF MORINGA PLANT

Abstract

The present study designed to investigate and evaluate the protective and beneficial effects of Moringa Oleifera lam. Extracts (ethanolic leaves extract (ELE), aqueous leaves extract (AQLE), ethanolic seeds extract(ESE) and aqueous seeds extract (AQSE) comparing with silymarin (SIL) against side effects of chemotherapy (cyclophosphamide), to avoid and decrease its harmful side effects. Therefore, to achieve this aim, seventy male albino rats divided into 7 groups each group contains 10 rats as the following: • Group 1 (control): Rats received distilled water orally (untreated check). • Group 2 (CYP): Cyclophosphamide 150 mg/kg body weight was given through its intra-peritoneal twice; one dose on the15th day and another dose on the 30th day. • Group 3 (ELE+CYP): Rats were administrated orally with ethanolic leaves extract 500 mg/kg/day orally through an intragastric tube for consecutive 7days before and 7days after CYP injection. • Group 4 (AQLE+CYP): received aqueous leaves extract 500 mg/kg/day for consecutive 7days before and 7days after CYP injection. • Group 5 (ESE+CYP): received ethanolic seeds extract 500 mg/kg/day for consecutive 7days before and 7days after CYP injection. • Group 6 (AQSE+CYP): received aqueous seeds extract 500 mg/kg/day for consecutive 7days before and 7days after CYP injection. • Group 7 (SIL+CYP): Rats were administrated aqueous solution of silymarin 100 mg/kg/day by gavage for consecutive 7days before and 7days after CYP injection. The adverse effects occurring for experimental rats injected with CYP were investigated through of histopathological assay of hepatocytes, hematological analyses and different blood biochemical determinations (e.g enzymes activity of. AST, ALP, ALT, CPK, and LDH, glucose, total protein, albumin, lipid profile, creatinine, uric acid, urea & lipid peroxidation level).