Assessment of the role of total antioxidant capacity and troponin I as possible predictors for phosphides -induced cardiotoxicity

Abstract

Outcome of the studied patients was determined as the following ; the majority of patients (92 %) recovered and discharged without any complications and only 2.7% died. eleven cases (5.9%) had shock, 8 cases (4.3%) developed cardiac arrest, 8 cases (4.3%) developed respiratory failure, and 11 cases (5.9%) developed myocardial ischemia. The area under the curve was 0.765(0.697 to 0.824), the best cut off point was ≤0.07 µmol/l, with sensitivity of 100% and specificity of 63.54% for TAC to predict mortality among studied patients. The area under the curve was 0.97(0.94 to 0.99), the best cut off point was ≥2.95ng/ml, with sensitivity of 100% and specificity of 90.06% for troponin I to predict mortality among studied patients. The current study concluded that Initial TAC ≤0.07µmol/l and troponin I ≥2.95ng/ml levels could be useful in predicting development of oxidative damage, cardiotoxicity and mortality after metal phosphides poisoning. The present study recommended the use of TAC and troponin I levels in patients with acute metal phosphides toxicity for prediction of cardiotoxicity and mortality.