The Association between Silent Mating Type Information Regulator 2 Homolog 1 (SIRT1) Gene Polymorphism and Systemic Lupus Erythematosus (SLE)

Abstract

ystemic lupus erythematosus (SLE) is a chronic severe multisystem autoimmune disease that affects multiple organs being characterized by heterogeneous manifestations that may affect the skin, joint, heart, brain, kidney, hematopoietic and central nervous systems. It is characterized by autoantibody production for a variety of self-antigens, but it is specifically associated with anti-double stranded DNA (anti-dsDNA), and immune complex deposition. The Lupus Foundation of America estimates that 1.5 million Americans, and at least five million people worldwide, have a form of lupus. The SIRT1 is a member of sirtuin family of histone deacetylase enzymes that has been implicated in a variety of physiologic and pathologic events, including energy metabolism, inflammation, cell survival, and age-related alterations. On the light of the previous data, the present study was conducted to investigate the association of SIRT1 rs3758391 gene polymorphism with SLE and to study its impact on disease progression to lupus nephritis. This was a case control study, conducted in the Clinical Pathology Department, Ain Shams University Hospitals in the period between December 2018 till September 2019. The study