Hepatoprotective assessment of some essential oils against oxidative injuries induced by acetaminophen in rats

Abstract

The liver is the vital organ that performs essential functions including detoxification of deleterious materials. Drugs are the principal cause of hepatic injury that resulting in substantial clinical problem all over the world. Acetaminophen is considered one of the most used analgesics. Hepato- renal dysfunction is considered as one of the numerous problems in drug therapy. Numerous herbal medicines were evaluated both in vitro and in vivo for their hepatoprotective efficacy all over the world. Cardamom is used in medicine to treat gastrointestinal disorders. Little information has been reported on the antioxidant activity of aromatic oily liquid which can be obtained by steam distillation from native cardamom seeds. Thus, this study was designed to investigate the anticipated hepatoprotective activity of cardamom oil as compared to silymarin as standard drug against PCM-induced hepato-renal toxicity in adult male albino rats. Such task was achieved through the assessment of hematological, serum biochemical and histopathological changes associated with the administration of PCM and/or the herbal extracts to albino rats.