Transcranial Doppler (TCD) in Detection of Silent Cerebral Microangiopathy in Diabetic Patients

Abstract

Microangiopathic involvement is the most characteristic and widespread damage due to diabetes. Silent cerebral microangiopathy affecting diabetic patients with concomitant signs of microangiopatliic damage in other districts is a proposed hypothesis. The aim of this work is to study the validity of a simple non invasive tool transcranil Doppler ultrasonogq1phy (TCD) in the early detection of silent cerebral microangiopathy affecting diabetic patients. This study included 60 normotensive, stroke-free diabetic patients with ! i type-2 diabetes mellitus (DM) and 20 age-matched control subjects. TCD parameters I , (Pulsatility index, resistivity index, systolic/diastolic ratio) were statistically significant higher in diabetic patients than controls. Comj)HCated diabetics with retinopathy showed . significantly higher (PI) compared to non-complicated, also (PI) was found to be '

I significantly, and positively co:rrelated to the disease duration. These findings confirm the hypothosis of diabetes-related cerebral hemodynamic changes and suggests that the (PI), (RI),

and (SID) ratio reflect microangiopathic changes of cerebial vessels.