The Diagnostic Value Of Normalized ADC Using Spleen As A Reference Organ In Assessment Of Liver Fibrosis

Abstract

L iver fibrosis is a healing response to injuries caused by multiple types of chronic liver disease. Liver fibrosis in chronic liver disease results from excessive accumulation of an extracellular matrix in response to chronic inflammation (Feier D et al, 2015). Beyond being a marker of hepatic injury, fibrosis appears to play a direct role in the pathogenesis of cirrhosis, hepatocellular carcinoma, and portal venous hypertension, leading to increased morbidity and mortality. Viral hepatitis C infection represents the most common cause of hepatic fibrosis in Egypt (Castera L, 2012).