THE EFFECT OF DIMETHYLNITROSAMINE ON THE ACTIVITIES OF RENAL SULFOTRANSFERASES AND ARYLSULFATASES IN SCHISTOSOMA MANSONI INFECTED MICE

Abstract

N-nitroso compounds are an important class of environmental carcinogens and their role as causative agents in the pathogenesis of some human cancers is being investigated. Additionally, environmental problems including exposure to helminthic infection which is widely distributed in Egypt is closely related to renal disorders in patients infected with schistosomiasis. At the renal glomeruli of these patients, immune complex could be detected by flourescent anti-immunoglobulin or anti-C3 antibodies. The same phenomena have been observed in experimental animals infected with Schistosoma mansoni. The study was carried out on 400 male Swiss albino mice divided into the following groups: Group I: The control normal mice included 80 mice. Group D: Infected gorup, included 100 mice infected with Schistosoma mansoni cercariae. Group m: Treated group, included 100 mice, injected with N­ nitrosodimethylamine (7 mg DMN/kg body wt). Group IV: Infected-treated group, included 120 mice, injection with DMN was performed after week of infection.