Evaluationof the effect of glycemic control onthe Growth and its relation to Insulin like growth factor binding protein type 3 ina sample of prepubertal Egyptian children with type 1 Diabetes Mellitus

Abstract

T1DM is one of the most common chronic diseases diagnosed in childhood (Patterson, et al., 2009). It is a chronic disorder with well-known short and long term consequences. One of the long−term consequences is severe impairment of growth and development, (Daneman, et al., 2006). In this study we aimed to evaluate the effect of glycemic control on IGFBP-3 and growth in a sample of prepubertal Egyptian children with T1DM. Our cross sectional study, was conducted on 80 prepubertal Egyptian children, aged 12 or less, during the period from July 2018 to August 2019. 50 of the subjects had T1DM, the subjects were recruited from the outpatient clinic of the pediatric department of Ain shams university hospitals and Pediatric outpatient clinic of National Institute of Diabetes and Endocrinology, they were classified into three groups (Group I, II and III ). All participants were subjected to full medical history taking, including a 1 day recall nutritional questionnaire, general clinical examination including anthropometric measurements (weight and height) and laboratory investigations including (Hb, s. creatinine, AST, ALT, fT4 and TSH, FBS, 2 hours PP, HbA1c, s. IGFBP-3).