Protective Effect of Moringa olifera Extract against Rimactazid induced Hepatotoxicity in Rats

Abstract

Hepatotoxicty, the most important problem worldwide gets the most attention from scientists as it considered a lethal disease. It arises as a side effect of many drugs, Alcohol abuse, liver malfunction and others. RimactazidR (RimR) is the first line drug for tuberculosis causes hepatotoxicity. Our study asses the hepatoprotective effect of Moringa olifera (MO) leaves water extract towards the hepatotoxicity induced by RimR in rats. Eighty – eight rats (100-120g) were divided into 10 groups (7 rats for normal, drug, Moringa extract only (200 and 1600 mg) groups and 10 rats for Moringa extract&drug with different methods of administration for each group). Co-administration of Moringa oleifera with RimR reduced the elevated serum ala¬nine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), total protein, total bilirubin levels, triglyceride (TG), cholesterol (CHOL), High-density lipoprotein (HDL- cholesterol), Low-density lipoprotein (LDL), creatinine, urea, malondialdehyde (MDA) and total antioxidant capacity (TAC). However, it elevated the reduced albumin. Histopathological examination of MO extract groups showed the reduction in liver damage happened by RimR adminstration.