Synthesis and Reactions of Some Heterocyclic and Poly Heterocyclic Nitrogen Compounds with Expected Biological Activities

Abstract

This work aimed to synthesize novel biologically active compounds as anticancer or antiviral agents through the following three parts Part 1: Synthesis, Molecular Modeling and Anti-Proliferative Activity of Novel Fused Tricyclic Pyrazole and Pyridine Derivatives Derived From 2-Arylsubstituted 1,3-Indandione. 1,3-Indandione 1 was reacted with aromatic aldehydes 2a–e to give the corresponding 2-aryl substituted derivatives 3a–e. One-pot reaction of 1,3-indandione with ethyl cyanoacetate and aromatic aldehydes 2a-b via intermediates A and B affording 2-pyridinone derivatives 4a-b (Scheme