DETECTION OF SOME CARCINOGENIC AROMATIC AMINES IN WATER ENVIRONMENT IN WEST INDUSTRIAL REGION OF ALEXANDIRIA AND THEIR EFFECT ON RATS

Abstract

Aromatic amines, which are essential to the chemical industry, comprise a common group of contaminants in fresh water and marine system. Therefore, the present study was directed to investigate the pollution of lake Mariut and El-Mex bay with there aromatic amines viz, a-naphthylamine, J3-naphthylamine and benzidine in water as well as in the muscle tissues of four types of fish. The results recorded that there is a big amount of the three studied amines with a significant effect of place on the distribution of the three amines. The concentration of amines was maxintum in Moharam bey and El-Kalaa drains due to run off industrial wastes. On the other hand, the results obtained from six stations of EI­ Mex bay represent the variation in the concentration of the three amines in six stations seasonally according to places which depend on near of or a way from the run of pollutants. In the fish flesh elevated levels of the three amines was found higher in claris than in tilipia. This variation may be due to the food habits, increase in body size and higher fat content in claris than in tilipia. Also, remarkable variations in the concentration of the three amines were found in the muscle tissues of Saragus-saragus and Siganus­ rivulantus. This may be due to food habits In this respect this study was also endeavored to elucidate the biochemical, immunollogical and histopathological effects the three amines either in polluted fish flesh or added to diets as it on the rat's liver, kidneys and urinary bladder; since it was reported that the metabolism