Evaluation of brain iron content in Egyptian Patients with Sickle cell disease and its impact on Neurocognitive functions
Hanaa Midhat Abdel Gader Hussein;
Abstract
Background: Sickle cell disease (SCD) is considered the most prevalent monogenic diseases worldwide. Iron overload is one of its major complications especially those who required frequent transfusion. MRI is a reliable and non-invasive method for quantifying iron concentration in many organs as the liver and heart. Children with SCD are at a high risk for neurocognitive impairment; they often scored lower on general IQ measures than healthy children which may be due to iron overload in brain tissue.
Primary objective: To assessed brain iron content (using R2* values) in the caudate and thalamic regions through quantitative brain MRI study in SCD patients in comparison to age and sex-matched healthy controls. Secondary objective: To evaluate the impact of brain iron content on neurocognitive functions assessed by neurocognitive examinations.
Methods: 32 children and young adults (19 males, 13 females) with SCD and 11 control persons (5 males, 6 females) were recruited. Brain MRI study using multi-echo fast gradient echo sequence was performed for only 15 SCD patients and 11 controls. Brain R2* values of both caudate and thalamic regions (right and left sides) were calculated. All SCD patients were examined for the neurocognitive functions; Wechsler IV Intelligence Scale (verbal, perceptual, memory, processing and total IQ) and Benton Visual Retention Test.
Results: No statistically significant differences were found between SCD and control group in all regions of interests in brain MRI. No statistically significant differences were found between the two subgroups (p>0.05) in right thalamus, left and right caudate regions. 62.5% SCD patients had anxiety; 4.2%, 8.3% and 50% had severe, moderate and mild anxiety respectively.
Conclusion: Although children and young adults with SCD had high prevalence of neurocognitive dysfunction, this could not be explained by brain iron overload alone which might be slowly accumulating iron.
Primary objective: To assessed brain iron content (using R2* values) in the caudate and thalamic regions through quantitative brain MRI study in SCD patients in comparison to age and sex-matched healthy controls. Secondary objective: To evaluate the impact of brain iron content on neurocognitive functions assessed by neurocognitive examinations.
Methods: 32 children and young adults (19 males, 13 females) with SCD and 11 control persons (5 males, 6 females) were recruited. Brain MRI study using multi-echo fast gradient echo sequence was performed for only 15 SCD patients and 11 controls. Brain R2* values of both caudate and thalamic regions (right and left sides) were calculated. All SCD patients were examined for the neurocognitive functions; Wechsler IV Intelligence Scale (verbal, perceptual, memory, processing and total IQ) and Benton Visual Retention Test.
Results: No statistically significant differences were found between SCD and control group in all regions of interests in brain MRI. No statistically significant differences were found between the two subgroups (p>0.05) in right thalamus, left and right caudate regions. 62.5% SCD patients had anxiety; 4.2%, 8.3% and 50% had severe, moderate and mild anxiety respectively.
Conclusion: Although children and young adults with SCD had high prevalence of neurocognitive dysfunction, this could not be explained by brain iron overload alone which might be slowly accumulating iron.
Other data
| Title | Evaluation of brain iron content in Egyptian Patients with Sickle cell disease and its impact on Neurocognitive functions | Other Titles | تقييم محتوى الحديد في الدماغ لدى المرضى المصريين المصابين بمرض الخلايا المنجلية وأثره على الوظائف المعرفية العصبية | Authors | Hanaa Midhat Abdel Gader Hussein | Issue Date | 2019 |
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