Clinical, Laboratory, Endoscopic and Histological Correlation to Assess Actual Remission in Patients with Ulcerative Colitis

Abstract

Ulcerative colitis (UC) is an idiopathic inflammatory disease of the colon which results in diffuse friability and superficial erosions on the colonic wall associated with bleeding. It is the most common form of inflammatory bowel disease (IBD) worldwide. Targets of therapy in ulcerative colitis (UC) have witnessed a paradigm shift from only symptomatic improvement to mucosal healing and recently even histological healing. Endoscopic inactivity does not always correlate with histological inactivity. Ongoing histological activity may be associated with the increased risk of disease relapse even in patients with endoscopically normal mucosa. Moreover, histological inflammation has also been shown to be associated with increased risk of dysplasia in patients with UC. This was a Prospective observational study conducted on 30 patients to evaluate the correlation between clinical remission, laboratory and inflammatory markers, endoscopic and histological remission in patients with ulcerative colitis and to assess to what extent clinical remission affects “treat to target” policy.