A study on optimization of microencapsulation process using experimental design

Abstract

The development of a new pharmaceutical formulation is usually an optimization problem. The application of optimization technique, consisting of statistically experimental design, to pharmaceutical formulation development would provide an efficient and economical method to acquire the necessary information to understand relationship between independent variables and dependent variables. In addition optimization process provides a method to develop an empirical model equation to characterize the response as a function of different independent variables. The work in this thesis is a trial to apply optimization of microencapsulation using statistical models. The capacity of microencapsulation to change the surface properties was chosen as a target.