Comparative study between Gabapentin, Midazolam and Granisterone in management of post operative nausea and vomiting in C.S

Abstract

Postoperative nausea and vomiting (PONV) is an important clinical problem that still affects patients undergoing surgery with general anaesthesia. With no prior prophylaxis, approximately 30% of all patients suffer from nausea and vomiting in the post-anaesthetic period, whereby the highest incidence can be found in the first 6 hours after surgery. Compared to the many studies about PONV, little attention has been paid to nausea and vomiting occurring during or after regional anaesthesia. These techniques gain increasing attention. Nowadays, about 7% of all surgical procedures worldwide are caesarean sections (CSs) and the majority of them are performed with neuraxial blockades. Especially in these patients, nausea and vomiting are also present during the surgical procedure causing discomfort for the parturient, impair surgical conditions for the obstetrician and can lead to medical side effects such as aspiration of gastric content, enhanced intra and postoperative pain and even bleeding or surgical trauma. Pain is the worst fear of women undergoing caesarean delivery. Post-caesarean delivery pain hinders the mother’s ability to care for and feed her newborn infant. Hence, the