Psychopathology in offspring of parents with Bipolar affective disorder in an Egyptian sample

Abstract

Bipolar affective disorder (BD) is a neuropsychiatric disorder characterized by extreme fluctuations mood shifts alternating between episodes of mania and depression (Craddock and Sklar, 2013). Depressive episodes are associated with sad mood, suicidality, impaired cognition, and anhedonia whereas Manic symptoms includedecreased sleep, high-risk actions, and impulsivity, (Barnett &Smoller, 2009).So, the estimated lifetime prevalence of BD is 1 to 3 percent worldwide (Pedersen et al., 2014). In 60% there is evidence of inherited of mood disorder fromfamily members referring a potentially large genetic contribution to the disorder(Senda et al.,2019). Genetic factors in bipolar affective disorder tends to be familiar, about half the people with Bipolar affective disorder have family member with a mood disorder, such as depression. To person who has one parent with bipolar disorder has a 15 to 25 % chance of having the incidence. A person who has a non-identical twin with the disorder has a 25% chance of disorder, the same risk as if both parents have BD. A person who has an identical twin with Bipolar affective disorder has an even higher risk of developing the disorder about an eightfoldhigher risk than a non-identical twin (Goretti et al.,2017).