Role of Autologous Platelet Rich Plasma (PRP) in Hypospadias Repair

Abstract

PRP has been expressing promising results in healing promotion since its usage in in-situ regenerative therapy techniques in surgery, orthopaedics, and sports medicine. We usedthe results of hypospadias repair with PRPg in comparison to the results of hypospadias repair without PRPto prove the paramount role of PRP in healing, limitation of post-operative complications, and enhancement of cosmosis.

The prevalence of hypospadias is estimated to be 11.3 of 10000 to affect less than 0.1% of newborns worldwide. The etiology of hypospadias is multifactorial; environmental factor, genetic factors, maternal-placental factors, in addition to prenatal insufficient hormonal stimulation. Several repair techniques have been developing to improve the outcomes including tissue healing, and to reduce the risk of complications including stenosis glans dehiscence, hematoma, phimosis, fistula, infection, graft retraction and edema. In arandomized prospective controlled study, we included 60 children who aged between 6 months and 12 years. During two years, we recruited patients from Pediatric Surgery department at Ain Shams University Hospital, and Pediatric surgery unit at Suez Canal University Hospital. The study aim was achieved through assessment of the patients’ characteristics, intraoperative measures and comparison of the rate of complications of autologous PRPg versus TIP in hypospadias repair. In this study we divided the study population into two groups as following: Group 1A: we used TIP repair with autologous PRP gel; Group 1B: we used TIP repair without autologous PRP gel; Group 2A: we used buccal mucosa or foreskin graft as first stage with autologous PRP gel; and Group 2B: we used buccal mucosa or foreskin graft as first stage without autologous PRP gel.