Impact of Oral Nicorandil Intake on Incidence of Acute Kidney Injury in Diabetic Patients with Renal dysfunction Undergoing Elective Percutaneous Coronary Intervention

Abstract

C ontrast-induced acute kidney injury (CI-AKI) is a serious and prevalent side effect of the administration of iodine contrast medium after Coronary angiography or Percutaneous Coronary Intervention procedures. The European Society of Urogenital Radiology defines contrast-induced acute kidney injury as any of the following (Kellum J. et al., 2012): • Increase in Serum creatinine by more than or equal 0.3 mg/dl within 48 hours. • Increase in serum creatinine to more than or equal to 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days • Urine volume less than 0.5 ml/kg/h for 6 hours CI-AKI incidence ranges from 2-5% in the general population to 50% in high-risk patients (Cheungpasitporn et al., 2014).