Molecular genetic, Embryologic and Cytogenetic Studies on the effects of Bisphenol A(BPA)in Albino Rats

Abstract

Bisphenol A(BPA) is an endocrine disruptor chemical which used in the manufacturing process of plastic. Exposure to low doses on long periods of BPA had many hazardous effects. The aim of the present study was to assess the effects of lowest dose of BPA (50μg/kg b.w.) induced orally on the male reproductive performance and changes in the testis tissue through histological investigation. The effects of BPA on pregnant mother female rats and their fetuses morphologically and by skeletal examination. As well as the evaluation of the gene exp ression of the tumor suppressor gene P53 by quantitative Realtime PCR was carried out. The present study had been performed to investigate the adverse effects of BPA treatment on the male sperm quality; the sperm count, motility, progression, viability and sperm morphology abnormalities like head or/ and tail abnormalities. The histological architecture of the testis was also examined for any irregularities. Pregnant mother rats and their fetuses was investigated by measuring and examining the maternal body weights during pregnancy, abortion rates and percentage of resorption. The fetuses were investigated morphologically for any