Study of the effect of intradialytic exercise on the bone profile in prevalent hemodialysis patients

Abstract

Chronic kidney disease – mineral and bone disorder (CKD-MBD) is a systemic disorder manifested by one or more of the following: abnormalities in serum calcium, phosphorous, parathyroid hormone (PTH), or vitamin D, and also bone histological lesions marked by changes in bone turnover, mineralization, volume, growth and the presence of extraosseous vascular or other soft tissue calcification (Xiong, 2020). The Kidney Disease Improving Global Outcome (KDIGO) recommended the measurement of serum PTH or bone specific alkaline phosphatase (BALP) to evaluate bone disease and monitor bone turnover in CKD (Fidan, et al 2016). Biochemical markers of bone metabolism that reflect the cellular activity related to the formation and resorption of bone are useful in monitoring physical activity, and can help us understand the effects of exercise on bone (Maïmoun and Sultan 2011). Not only does exercise preserve bone mass by stimulating bone formation and reducing bone resorption but also helps prevent falls by insuring Coordination, self-assurance, and appropriate muscular strength (Chodzko, et al. 2009). The aim of this study is to evaluate the effect of intradialytic exercise training on bone markers in prevalent hemodialysis (HD) patients. The study was done on 40 patients with end stage renal disease on regular HD recruited from hemodialysis unit at Ain Shams University Hospital. Patients were equally divided into exercise group who participated in exercise program and control group matched for age, sex and BMI acted as controls and did not participate in exercise in any form.