EFFECT OF SOME PLANT EXTRACTS ON HYPERPROLACTINEMIA IN EXPERIMENTAL ANIMALS

Abstract

Hyperprolactinemia is one of the most important diseases now that medicine is currently concerned with. There are many causes that cause it and exist in our normal life, including psychological and nervous stress, tension and many medicines, including anti-vomiting drugs, schizophrenia medicines, hypnotics, sedatives, pituitary tumors and other reasons. Hyperprolactinemia leads to menstrual disturbances, delayed childbearing, and sometimes infertility in both males and females. Recently, great efforts have been focused on natural compounds and herbal ingredients without toxic and harmful effects to provide new therapeutic agents for hyperprolactinemia, so this study was conducted to evaluate the therapeutic effects of alcoholic extracts of marjoram leaves and sage leaves celery seeds against hyperprolactinemia in male and female rats. The present study also aimed to compare the effectiveness of the three extracts and the drug used in the treatment, and to achieve these goals, the following biological experiment was achieved: Sixty males and females albino rats of Wistar strain weighing about 100g were obtained from the farm of experimental animals in Helwan, Cairo, Egypt. The rats were housed under normal laboratory conditions. The rats had free access food and water ad libitum during the experiment period. Rats were randomly divided into 12 groups (n = 12), “6 groups of females and 6 groups of males”. And the first group in both males and females was left without treatment (the negative control group), then hyperprolactinemia was induced in the five groups in both males and females by metoclopramide - an anti-dopamine - (150 mg / kg / day) for a week by mouth and the prolactin hormone was analyzed to confirm the occurrence of infection. A group of females and males were left without any comparison treatments (positive control group), the third group in both groups were given a chemical drug used to lower the prolactin