Biological, Mechanical and Physical Evaluation of Glass Ionomer Functionalized with Two Different Chlorohexidine Derivatives: An in Vitro Study

Abstract

The main objective of this study was to investigate the effectiveness of adding chlorhexidine derivatives (digluconate and hexametaphosphate) using glass ionomer cement (GIC) with modified concentration (0.25%, 0.75%, 1.5%) as a restorative material in the treatment for secondary caries. Another objective of this study is to test the local and general effects of chlorhexidine in the GIC, chlorhexidine digluconate and chlorhexidine hexametaphosphate when mixed with GIC with different conc. at different time periods 7 days, 3months and 6 months. Antibacterial effect was tested by agar diffusion against oral bacteria streptococcus mutans and lactobacillus acidophilus that are the main cause of dental caries. Differences in inhibition zones at these time points were used to investigate the antimicrobial effect of the two restorations over the 6-month period. In addition, fluoride release and chlorhexidine release were tested in the laboratory to assess the time duration of the release over a period of 6 months to reassure release over this period. Compressive strength was tested after adding chlorhexidine to glass ionomer with different concentrations after 7 days and 6 months' storage period. Also, initial setting time was measured.