Carbetocin versus Oxytocin in Caesarean Delivery: Influence on Perioperative Nausea, Vomiting and Hemodynamic Changes

Abstract

C aesarean delivery has a lot of complications like hemodynamic changes, nausea and vomiting and some scenarios are life threatening complications as post-partum hemorrhage (PPH). The prevalence of PPH is approximately 6% of all deliveries (Carroli et al., 2008). In high-resource countries, PPH is the main cause of acute severe maternal morbidity, and of pregnancy-related ICU admissions. In addition to the direct consequences of acute hypovolemia, PPH exposes the women to the complications of transfusion, of intensive care and to infertility in case of hysterectomy. The main risk factors for PPH are factors of uterine atony, but they are globally poorly predictive. Risk factors related to components of care during labor and delivery are amenable to change, and the assessment of their risks-benefits balance should take into account the associated risk of PPH (Deneux-Tharaux et al., 2014). The third stage of labor has traditionally been defined as the time between the birth of the baby and the delivery of the placenta and membranes. It is the third stage that is the most perilous for the woman because of the risk of postpartum hemorrhage (PPH). The third stage of labor typically lasts between 10 and 30 minutes; if the placenta fails to separate within 30 minutes after childbirth, the third stage is considered to be prolonged. If the third stage of labor lasts longer that 18 minutes, it is associated with a significant risk of PPH; and there is a six-fold increase in PPH when the third stage of labor lasts longer than 30 minutes (Güngördük, ‎2018).