ROLE of SERUM ZINC, URINARY SODIUM and URINARY URIC ACID in MULTIPLE SCLEROSIS in EGYPT

Abstract

Multiple sclerosis is an inflammatory and neurodegenerative demyelinating disease of the CNS beginning in early adulthood, mostly autoimmune in origin. The etiology of the MS is not well understood; it is known as a multifactorial disease, which results from complex interactions between genetic predisposition and environmental factors. Understanding of these factors can lead us to new and more effective approaches for prevention and management of the disease. (Amato et al., 2018) In our study, there were 90 subjects, divided equally into 3 groups; RRMS, SPMS and HC. MS patients were diagnosed according to McDonald criteria 2017 recruited from MS unit at Ain Shams University Hospitals. The subjects were assessed regarding their basic demographic data, serum Zn level, urinary Na and UA levels, and correlated these data with their state of disease activity and degree of disability. Regarding demographic data, both groups (MS and HC) were age and sex matched. There was predominance of women with female to male ratio 3.6:1 in MS patients and 3.2:1 in HC individuals. Range of age was (20-50) years in MS group and (20-48) in HC group. Regarding smoking state, 51.67% of MS patients were smokers and 48.33% of them were non-smokers, but in HC group, 56.67% of them were smokers and 43.33% of them were non-smokers.