Kinetic Studies of Drug Released from Polymeric Nanocomposites Using Advanced Analytical Techniques
Heba Maher Ramadan Abdelrazik;
Abstract
- This chapter contains general introduction regarding the work done and includes two parts:
• Part (I): It contains an overview about nanomedicine. The drug delivery systems (DDSs) based on nanomedicine proofed high potential and wide applicability that have distinct features related to nano-sized.
• Part (II): It illustrates the main principles and components of ISEs, wearable and integrated multi-parameter sensors and the promising real-time on-body monitoring, the different mechanisms of solid contact transduction types of ISEs, and novel designs for potentiometric sensors.
Chapter (II): Fabrication and characterization of Venlafaxine -loaded poly (lactic acid)/ polycaprolactone blends nanofibers for buccal drug delivery systems:
In this chapter, electrospun nanofiber mats are developed as a new vehicle of drug delivery systems (DDSs). Electrospinning is a highly sophisticated and robust technique used in the fabrication of ultrafine fibres from different electrostatic fluids. This research work focuses on blending poly (lactic acid) (PLA) and poly (ε-caprolactone) (PCL) at a ratio of (1:1) fixed at 10 wt%/v. Venlafaxine was loaded on PLA/PCL blend nanofibers. This was followed by in -vitro and ex-vivo studies using chicken pouch mucosa as a fitted buccal model. Also, Mathematical models for drug release kinetics were calculated
Chapter (III): Cost-effective solid contact potentiometric sensors based on imprinted receptors for fluvoxamine determination:
In this chapter, a simple, efficient, and reliable analytical method was developed and used for the determination of the fluvoxamine drug (FLV) in pharmaceutical preparations and biological fluids.
Chapter (IV): Imprinted polymeric beads-based screen-printed potentiometric platforms modified with multi-walled carbon nanotubes (MWCNTs) for selective recognition of fluoxetine:
In this chapter, we present a new validated potentiometric method for fluoxetine (FLX) drug monitoring. The method is based on the integration of molecular imprinting polymer (MIP) beads as sensory elements with modified screen-printed solid contact ion-selective electrodes (ISEs).
• Part (I): It contains an overview about nanomedicine. The drug delivery systems (DDSs) based on nanomedicine proofed high potential and wide applicability that have distinct features related to nano-sized.
• Part (II): It illustrates the main principles and components of ISEs, wearable and integrated multi-parameter sensors and the promising real-time on-body monitoring, the different mechanisms of solid contact transduction types of ISEs, and novel designs for potentiometric sensors.
Chapter (II): Fabrication and characterization of Venlafaxine -loaded poly (lactic acid)/ polycaprolactone blends nanofibers for buccal drug delivery systems:
In this chapter, electrospun nanofiber mats are developed as a new vehicle of drug delivery systems (DDSs). Electrospinning is a highly sophisticated and robust technique used in the fabrication of ultrafine fibres from different electrostatic fluids. This research work focuses on blending poly (lactic acid) (PLA) and poly (ε-caprolactone) (PCL) at a ratio of (1:1) fixed at 10 wt%/v. Venlafaxine was loaded on PLA/PCL blend nanofibers. This was followed by in -vitro and ex-vivo studies using chicken pouch mucosa as a fitted buccal model. Also, Mathematical models for drug release kinetics were calculated
Chapter (III): Cost-effective solid contact potentiometric sensors based on imprinted receptors for fluvoxamine determination:
In this chapter, a simple, efficient, and reliable analytical method was developed and used for the determination of the fluvoxamine drug (FLV) in pharmaceutical preparations and biological fluids.
Chapter (IV): Imprinted polymeric beads-based screen-printed potentiometric platforms modified with multi-walled carbon nanotubes (MWCNTs) for selective recognition of fluoxetine:
In this chapter, we present a new validated potentiometric method for fluoxetine (FLX) drug monitoring. The method is based on the integration of molecular imprinting polymer (MIP) beads as sensory elements with modified screen-printed solid contact ion-selective electrodes (ISEs).
Other data
| Title | Kinetic Studies of Drug Released from Polymeric Nanocomposites Using Advanced Analytical Techniques | Other Titles | دراسات حركية للعقاقير المنطلقة من المركبات النانوية البوليمرية باستخدام تقنيات تحليلية متقدمة | Authors | Heba Maher Ramadan Abdelrazik | Issue Date | 2021 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| BB8864.pdf | 3.2 MB | Adobe PDF | View/Open |
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