Randomized Clinical Trial to Evaluate the Efficacy of Tranexamic Acid in Irrigant Solution on Blood Loss in Transurethral Resection of the Prostate

Abstract

PH is a nonmalignant enlargement of the prostate gland caused by cellular hyperplasia of the glandular and stromal elements. Transurethral resection of prostate (TURP) is one of the most common and well-developed technologies used to treat BPH. It is recognized as the gold standard for surgical BPH treatments. Bleeding in TURP is a major complication as the prostate has a rich blood supply. Tranexamic acid (TXA) is an anti-fibrinolytic agent, which inhibits the fibrin degradation, so increasing the blood’s ability to form blood clots. The topical use of antifibrinolytic agents such as tranexamic acid (TXA) demonstrates benefit without any significant risk, systemic absorption and thromboembolic disorders. Tranexamic acid in irrigant fluid was safe and significantly reduced perioperative blood loss and requirement of blood transfusion during percutaneous nephrolithotomy. However, the role of tranexamic acid in irrigant fluid had never been studied in TURP. This study had been conducted to determine the efficacy and safety of using tranexamic acid in irrigant solution in reducing blood loss during TURP. A prospective, and a randomized clinical study of 50 male patients diagnosed with BPH and undergoing TURP were randomly distributed in 2 groups, group A (25 patients) TXA group, group B (25 patients) control group, operations were done in the Faculty Of Medicine (Ain Shams University).