Designing of molecularly imprinted polymers-Based Chemical sensors for the Detection of protein

Abstract

The aim of this work is to prepare and characterize biosensors to detect and quantify of some basic molecules and Portions in biological fluids. Chapter one The basic principles, historical background, classifications, selectivity, applicability, some strategies used in fabrication and application of potentiometric sensors. Chapter two It presents for the first time a novel potentiometric sensor based on the stimulus-responsive molecularly imprinted polymer (MIP) as a selective receptor for neutral dopamine determination. This smart receptor can change its capabilities to recognize according to external environmental stimuli. Therefore, MIP-binding sites can be regenerated in the polymeric membrane by stimulating with stimulus after each measurement. Based on this effect, reversible detection of the analyte via potentiometric transduction can be achieved. MIPs based on 4-