Prognostic Value of Platelet-To-Lymphocyte Ratio among Septic Patients with Acute Kidney Injury (A Prospective Cohort Study)

Abstract

idney is one of the most affected organs by sepsis causing acute kidney injury (AKI). Sepsis is a major cause of morbidity and mortality worldwide, and it results from a deregulation of the systemic inflammatory response to infection. Despite significant advances in understanding the pathophysiology and therapeutic strategies for sepsis, the mortality remains high, at 300 deaths per 100 000 people. An extremely complex systemic expression of inflammatory and anti-inflammatory response plays a critical role in the pathophysiological process of sepsis, which is strongly associated with an increased risk of mortality. Identifying patients who are at a high risk of poor outcomes, in the early stage of sepsis, is vital for timely and adequate intervention. While a significant amount of effort has been put into investigating promising biomarkers, the challenge of identifying these at risk patients remains. In recent years, studies have reported that platelets and lymphocytes play critical roles in the inflammatory process. Therefore, the platelet-to-lymphocyte ratio (PLR)-a novel