Evaluation of the Role of Pentraxin 3, B type Natriuretic Peptide and Troponin I in Acute Carbon Monoxide Cardiotoxicity

Abstract

arbon monoxide poisoning is one of the most frequent intoxications in the world. It is produced by incomplete combustion of carbonaceous substances. Exposure to high levels of CO may induce tissue hypoxia, cause tissue injury and even death. Cardiac toxicity after CO poisoning includes arrhythmias, heart failure and myocardial infarction. As these cardiac injuries may increase mortality in patients with CO poisoning, it is very important to detect cardiac injuries at the emergency department. However, the prevalence and clinical course in patients with acute CO poisoning has been insufficiently reported. The current study was carried out on 30 patients admitted to the PCC-ASUH with moderate or severe acute CO poisoning during the period from the beginning of October 2018 to the end of March 2020. The aim of this study was to assess the role of Pentraxin 3 and B type natriuretic peptide in comparison with cardiac Troponin I as early predictor biomarkers of cardiotoxicity in patients presented with acute CO poisoning to the PCC-ASUH.