Impact of Chitosan Intake on Nicotine Toxicity in Diabetic Rats

Abstract

Diabetes mellitus is a metabolic disorder in which the effectiveness of insulin /or the delivery of insulin to the tissues are reduced. It characterized by hyperglycemia usually accompanied by glucosuria. Chronic abnormality of glucose tolerance is an associated with long term damage and failure of various organ systems; mainly affecting the eyes, nerves, kidneys and the heart. Diabetes mellitus and cigarette smoking are major public health burdens. Both are strong risk factors for cardiovascular diseases (CDVs) and their co-occurrence have dramatic impact on the absolute risks challenged human health lead to increase the risk of mortality. COS is an amino polysaccharide derived from chitin which present in the exoskeleton of crustacean. It acts as antimicrobial, antioxidant, antifungal, antidiabetic, anti-obesity, anti-cancer, anti-inflammatory and anti-allergic agent due to its chemical and biological properties. The aim of this study was to investigate the impact of COS administration in case of nicotine toxicity in adult healthy and corresponding diabetic male rats.