Amyloid A in serum and ascetic fluid as a marker of spontaneous bacterial peritonitis

Abstract

Background; Diagnosis of Spontaneous Bacterial Peritonitis (SBP) depends mainly on ascetic fluid culture which may be negative in spite of the clinical suggestion of SBP and high ascetic fluid neutrophilic count, Aim and objectives; to assess the role of the clinical usefulness of the Amyloid A (serum and ascetic fluid) in patients with ascites (liver cirrhosis) and as a diagnostic marker for Spontaneous Bacterial Peritonitis, Subjects and methods; This is a Case-Control study, was conducted at Internal medicine and Gastroentrology outpatient clinics and ward in Ainshams University Hospitals and Shurook Hospital, on 50 patients divided into 2 groups; (group1): included 25 patients diagnosed with liver cirrhosis and ascites with spontaneous bacterial peritonitis (SBP), (group2): included 25 control subjects diagnosed with liver cirrhosis and ascites, Result; there was high statistically significant difference between the studied groups as regard amyloid, Conclusion; Although many research works showed the role of acute phase reactant (C-reactive protein (CRP) and Serum amyloid A (SAA)) in the inflammatory process and bacterial infections, this study focused on spontaneous bacterial peritonitis and assess the role of the clinical usefulness of the Amyloid A (serum and ascetic fluid) in patients with ascites (liver cirrhosis) and as a diagnostic marker for Spontaneous Bacterial Peritonitis, Keywords; Ascitic fluid, bacterial infections, C-Reactive Protein (CRP), diagnostic marker, Serum Amyloid A (SAA), Spontaneous Bacterial Peritonitis (SBP).