Management of some opportunistic microbial pathogens isolated from cancer patients using fungal nanoparticles.

Abstract

1-The immune system in the human body performs the process of defending the body against various microbes. People who suffer from immunodeficiency, especially cancer patients, lose the ability to fight these microbes and be a target for them, which may lead to death. 2- A collection of 283 samples from cancer patients were collected from the national cancer institute in Cairo, Egypt, from December 2016 to July 2018, from various sources such as blood, pus, urine, throat, tongue, and ear swab, etc. These samples were grown on different media like MacConkey agar, blood agar, and sabouraud dextrose agar to isolate the present microbes. 3- The isolated microbes were picked and were subjected to purification process and identification by standard microbiological methods (morphology, biochemical, and Vitek -2 system). 4- Results of identification of microbial isolates were revealed that 181 identified bacterial isolates were obtained as the following, Escherichia coli with frequency rate (34.80%), Klebsiella pneumonia (29.82%), Acinetobacter baummannii (13.81%), Pseudomonas sp. (8.83%), Enterobacter sp. (4.41%), Staphylococcus sp. (3.31%), Proteus mirabilis (1.65%). Citrobacter freundii (1.10%), Serratia marcescens (0.55%), Cedecea davisae (0.55%), Burkholderia cepacian (0.55%), Pantoea agglomerans (0.55%), Candida tropicalis (13.06%), Candida kruse (8.11%), candida albicans (7.41%), and Candida glabrata (7.41%). It was found that the number of bacterial isolates from adults was 146 isolates with a percentage of 51.53%, while the number of isolates in children was 35 isolates with a percentage of 12.35%, gram - negative bacteria was represented by 175 isolates represent 61.77% , while the gram-positive bacteria represented by 6 isola