Impact of Axillary Lymph Nodes Ratio on Outcomes of Non Metastatic, Triple Negative Breast Cancer Patients treated with Up Front Surgery (A Retrospective Study)

Abstract

reast cancer is the most common malignant tumor among females around the world. The Triple-Negative Breast Cancer (TNBC) group often shows a more aggressive course than other molecular subtypes. Axillary lymph node (LN) status is one of the most significant prognostic markers in breast cancer. This is a retrospective study evaluating impact of LNR on the disease free survival, overall survival &possibilityof recurrence in non metastatic triple negative breast cancer patients treated with up front surgery (cutoff point 0.2) In our retrospective analysis there was statistical significant difference in the primary endpoint of DFS between group I with LNR <0.2 and group II with LNR≥0.20 [Mean: 43.843months versus23.781 months; 3year DFS 68% versus 29.4% respectively]. P = 0.0049, although there was no statistical significant difference bretween these two groups in OS [Mean: 48.664 months versus37.531 months; 3year OS 78.6%versus65.4% respectively] P = 0.2618. Patients with high LNRs were associated with a hazard ratio of recurrence as compared with those in the low risk category similar to our study (40% of patients with LNR<0.20 relapsed versus60% of those with LNR≥0.20 [P = 0.0152].