Correlation of Serum Uric Acid Levels with Coronary Flow in Patients with ST-segment Elevation Myocardial Infarction undergoing Primary Coronary Intervention

Abstract

orldwide, ischemic heart disease is the single most common cause of death and its frequency is increasing. STEMI is a significant cause of morbidity and mortality in patients with coronary heart disease. PCI is considered to be the preferred reperfusion strategy for acute coronary syndrome (ACS). Despite optimal evidence-based PCI, periprocedural myocardial injury (PMI) and myocardial no-reflow phenomenon can still occur and are associated with a worse in-hospital and long-term prognosis. Angiographic no-reflow is defined as less than TIMI 3 flow or TIMI 3 flow with MBG 0 or 1 without angiographic evidence of mechanical vessel obstruction. Uric acid is an inexpensive laboratory test. Inflammatory effect of uric acid has been recently shown to have negative effect on cardiovascular outcomes in patients with STEMI. Our study aimed to assess the impact of Uric acid level prior to primary PCI in patients presenting with acute STEMI on myocardial perfusion. Results for age, gender, hypertension, smoking, family history dyslipidemia, and diabetes did not show any statistical significance of value between the cases and control groups.