Serum Level of IL33 in Gouty Renal Patients

Abstract

Gout, a common and a complex form of inflammatory arthritis that characterized by abnormally elevated levels of uric acid in the blood, which results from purine metabolism disorder. IL-33 is a member of the IL-1 cytokine family, and the intracellular pathway of IL-33 signaling is similar to that of IL-1 signaling. Recent studies have demonstrated that IL-33 played a critical role in obesity-associated inflammation, atherosclerosis, and metabolic abnormalities. Although the detrimental role for IL-33 in the RA and septic arthritis has been reported, the role of IL-33 in gout arthritis is still unknown. Our study aimed to investigate the serum level of IL- 33 in correlation with other renal pathogenic investigations among gouty patients. Which we assessed three groups, Group I: included 30 gout patients with normal kidney function, Group II: included 30 gout patients with kidney affection and Group III: 30 age and sex matched healthy subjects that included in the study as a control group. In these groups, we considered importantly the "Inclusion criteria" that all patients were diagnosed accordingly to the "American College of Rheumatology classification criteria", and we avoided "Exclusion criteria" that none of